Unfolded Protein Response (UPR)

Meyerovich K, Ortis F, Allagnat F, Cardozo AK. Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. J Mol Endocrinol. 2016 Jul;57(1):R1–R17. doi: 10.1530/jme-15-0306. PMID: 27067637.; Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008 May;29(3):317–33. PMID: 18436705; PMCID: PMC2528859.; Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev. 2008 Feb;29(1):42–61. doi: 10.1210/er.2007-0015. PMID: 18048764.; Schröder M. Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences. 2007 Nov 26;65(6):862–94. doi: 10.1007/s00018-007-7383-5.; Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773–84. PMID: 16365312; PMCID: PMC1316886.; Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005;74():739–89. doi: 10.1146/annurev.biochem.73.011303.074134. PMID: 15952902.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.4.21.112 site-1 protease
3.6.5.3 protein-synthesizing GTPase GTP phosphohydrolase (mRNA-translation-assisting)


Proteins

Protein ID name full name