Synthesis of Leukotrienes (LT) and Eoxins (EX)

Claesson HE. On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):120–5. doi: 10.1016/j.prostaglandins.2008.12.003. PMID: 19130894.; Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Journal of Lipid Research. 2009 Jun;50(6):1015–38. doi: 10.1194/jlr.r900004-jlr200.; Murphy RC, Gijón MA. Biosynthesis and metabolism of leukotrienes. Biochem J. 2007 Aug 01;405(3):379–95. doi: 10.1042/bj20070289. PMID: 17623009.; Hammarström S. Leukotrienes. Annu Rev Biochem. 1983;52():355–77. doi: 10.1146/annurev.bi.52.070183.002035. PMID: 6311078.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

14,15-LTC4

Formula: C30H47N3O9S (625.3032852)

CAS ID: 75290-60-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.13.11.-
1.13.11.12 linoleate 13S-lipoxygenase linoleate:oxygen 13-oxidoreductase
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase
1.13.11.34 arachidonate 5-lipoxygenase arachidonate:oxygen 5-oxidoreductase
2.3.2.2 gamma-glutamyltransferase (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
3.3.2.6 leukotriene-A4 hydrolase (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase
3.4.11.4 tripeptide aminopeptidase
3.4.13.19 membrane dipeptidase
3.4.19.13 glutathione gamma-glutamate hydrolase
3.4.19.14 leukotriene-C4 hydrolase
3.5.2.6 beta-lactamase beta-lactam hydrolase
4.4.1.20 leukotriene-C4 synthase leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
7.6.2.2 ABC-type xenobiotic transporter ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
7.6.2.3 ABC-type glutathione-S-conjugate transporter ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]


Proteins

Protein ID name full name