Apoptosis

MacFarlane M, Williams AC. Apoptosis and disease: a life or death decision. EMBO Reports. 2004 Jul;5(7):674–8. doi: 10.1038/sj.embor.7400191.; Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003 Nov 24;22(53):8590–607. doi: 10.1038/sj.onc.1207102. PMID: 14634621.; Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev. 2003 Oct 15;17(20):2481–95. doi: 10.1101/gad.1126903. PMID: 14561771.; Kerr JF. History of the events leading to the formulation of the apoptosis concept. Toxicology. 2002 Dec 27;181-182():471–4. doi: 10.1016/s0300-483x(02)00457-2. PMID: 12505355.; Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002 Sep;2(9):647–56. doi: 10.1038/nrc883. PMID: 12209154.; Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer. 2002 Jun;2(6):420–30. doi: 10.1038/nrc821. PMID: 12189384.; Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics. British Journal of Cancer. 1972 Aug;26(4):239–57. doi: 10.1038/bjc.1972.33.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.-.-.-
2.3.1.97 glycylpeptide N-tetradecanoyltransferase tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.5.1.58 protein farnesyltransferase farnesyl-diphosphate:protein-cysteine farnesyltransferase
2.5.1.59 protein geranylgeranyltransferase type I geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.39 ROCK-subfamily protein kinase ATP:cytoskeleton-protein phosphotransferase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.4.21.79 granzyme B
3.4.22.56 caspase-3
3.4.22.59 caspase-6
3.4.22.60 caspase-7
3.4.22.61 caspase-8
3.4.22.62 caspase-9
3.6.5.5 dynamin GTPase GTP phosphohydrolase (vesicle-releasing)
4.2.1.109 methylthioribulose 1-phosphate dehydratase S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]


Proteins

Protein ID name full name