Coenzyme A biosynthesis

Leonardi R, Zhang YM, Rock CO, Jackowski S. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar;44(2-3):125–53. doi: 10.1016/j.plipres.2005.04.001. PMID: 15893380.; Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crécy-Lagard V, Osterman A. Complete Reconstitution of the Human Coenzyme A Biosynthetic Pathway via Comparative Genomics. Journal of Biological Chemistry. 2002 Jun;277(24):21431–9. doi: 10.1074/jbc.m201708200.; Prohl C, Pelzer W, Diekert K, Kmita H, Bedekovics T, Kispal G, Lill R. The Yeast Mitochondrial Carrier Leu5p and Its Human Homologue Graves' Disease Protein Are Required for Accumulation of Coenzyme A in the Matrix. Molecular and Cellular Biology. 2001 Feb 01;21(4):1089–97. doi: 10.1128/mcb.21.4.1089-1097.2001.; Robishaw JD, Neely JR. Coenzyme A metabolism. American Journal of Physiology-Endocrinology and Metabolism. 1985 Jan 01;248(1):E1–9. doi: 10.1152/ajpendo.1985.248.1.e1.; LIPMANN F. On chemistry and function of coenzyme A. Bacteriol Rev. 1953 Mar;17(1):1–16. PMID: 13032008; PMCID: PMC180754.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

(R)-4'-phosphonatopantothenate(3-)

Formula: C9H15NO8P (296.05352600000003)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.24 dephospho-CoA kinase ATP:3'-dephospho-CoA 3'-phosphotransferase
2.7.1.33 pantothenate kinase ATP:(R)-pantothenate 4'-phosphotransferase
2.7.7.3 pantetheine-phosphate adenylyltransferase ATP:pantetheine-4'-phosphate adenylyltransferase
4.1.1.36 phosphopantothenoylcysteine decarboxylase N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)
6.3.2.51 phosphopantothenate-cysteine ligase (ATP) (R)-4'-phosphopantothenate:L-cysteine ligase (ATP-utilizing)


Proteins

Protein ID name full name