Cleavage of the damaged purine

Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.; Saparbaev M, Laval J. Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases. Proc. Natl. Acad. Sci. U.S.A. 1994 Jun 21;91(13):5873–7. doi: 10.1073/pnas.91.13.5873.

Metabolites

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

1,N6-Ethenoadenine

Formula: C7H5N5 (159.054493)

CAS ID: 13875-63-3

spiroiminodihydantoin

Formula: C5H5N5O3 (183.039238)

CAS ID: 480996-13-2

5-guanidinohydantoin

Formula: C4H7N5O2 (157.0599722)

CAS ID: 104184-01-2



Enzyme

EC Number name full name note
3.2.2.-
3.2.2.21 DNA-3-methyladenine glycosylase II alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
3.2.2.31 adenine glycosylase adenine-DNA deoxyribohydrolase (adenine-releasing)
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase


Proteins

Protein ID name full name