Regulation of TP53 Activity

Mantovani F, Zannini A, Rustighi A, Del Sal G. Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships. Biochimica et Biophysica Acta (BBA) - General Subjects. 2015 Oct;1850(10):2048–60. doi: 10.1016/j.bbagen.2015.01.013.; Santiago A, Li D, Zhao LY, Godsey A, Liao D. p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1. Mol Biol Cell. 2013 Sep;24(17):2739–52. PMID: 23825024; PMCID: PMC3756925.; Meek DW, Anderson CW. Posttranslational Modification of p53: Cooperative Integrators of Function. Cold Spring Harbor Perspectives in Biology. 2009 Oct 28;1(6):a000950. doi: 10.1101/cshperspect.a000950.; Kruse JP, Gu W. Modes of p53 regulation. Cell. 2009 May 15;137(4):609–22. PMID: 19450511; PMCID: PMC3737742.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.-
2.1.1.320 type II protein arginine methyltransferase S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
2.1.1.361 [histone H4]-lysine20 N-methyltransferase S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase
2.1.1.367 [histone H3]-lysine9 N-methyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.12.1 dual-specificity kinase ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.1.3.78 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
3.4.19.12 ubiquitinyl hydrolase 1
3.5.1.98 histone deacetylase histone amidohydrolase
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name