Metabolic disorders of biological oxidation enzymes

Azimi F, Jafariyan M, Khatami S, Mortazavi Y, Azad M. Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia. Iran J Ped Hematol Oncol. 2014;4(1):32–8. PMID: 24734162; PMCID: PMC3980020.; Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). J Clin Aesthet Dermatol. 2013 Nov;6(11):45–8. PMID: 24307925; PMCID: PMC3848652.; Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci. 2013 Oct 18;14(10):21021–44. PMID: 24145751; PMCID: PMC3821656.; Sticova E, Jirsa M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol. 2013 Oct 14;19(38):6398–407. PMID: 24151358; PMCID: PMC3801310.; Pikuleva IA, Waterman MR. Cytochromes P450: Roles in Diseases. Journal of Biological Chemistry. 2013 Jun;288(24):17091–8. doi: 10.1074/jbc.r112.431916.; Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013 Apr;138(1):103–41. doi: 10.1016/j.pharmthera.2012.12.007. PMID: 23333322.; Nebert DW, Wikvall K, Miller WL. Human cytochromes P450 in health and disease. Philos Trans R Soc Lond B Biol Sci. 2013 Feb 19;368(1612):20120431. PMID: 23297354; PMCID: PMC3538421.; Millington GW. Obesity, genetics and the skin. Clin Exp Dermatol. 2013 Jan;38(1):50–6; quiz 56. doi: 10.1111/ced.12024. PMID: 23252752.; Mudd SH. Hypermethioninemias of genetic and non-genetic origin: A review. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):3–32. doi: 10.1002/ajmg.c.30293. PMID: 21308989.; Shih JC. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. 2004 Jan;25(1-2):21–30. doi: 10.1016/s0161-813x(03)00112-8. PMID: 14697877.

Metabolites

11-Deoxycortisol

Formula: C21H30O4 (346.214398)

CAS ID: 152-58-9

18-Hydroxycorticosterone

Formula: C21H30O5 (362.209313)

CAS ID: 561-65-9

6-Mercaptopurine

Formula: C5H4N4S (152.0156664)

CAS ID: 50-44-2

9-cis-Retinoic acid

Formula: C20H28O2 (300.2089188)

CAS ID: 5300-03-8

Androstenedione

Formula: C19H26O2 (286.1932696)

CAS ID: 63-05-8

Bilirubin-glucuronoside

Formula: C39H44N4O12 (760.2955584)

CAS ID: 27071-67-6

Calcidiol

Formula: C27H44O2 (400.3341124)

CAS ID: 19356-17-3

Calcitriol

Formula: C27H44O3 (416.3290274)

CAS ID: 32222-06-3

Corticosterone

Formula: C21H30O4 (346.214398)

CAS ID: 50-22-6

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Progesterone

Formula: C21H30O2 (314.224568)

CAS ID: 57-83-0

Retinoate

Formula: C20H28O2 (300.2089188)

CAS ID: 302-79-4

Trimethylamine

Formula: C3H9N (59.0734954)

CAS ID: 75-50-3

Vitamin D3

Formula: C27H44O (384.3391974)

CAS ID: 67-97-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.14.13.-
1.14.14.24 vitamin D 25-hydroxylase calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
1.18.1.6 adrenodoxin-NADP+ reductase adrenodoxin:NADP+ oxidoreductase
1.4.3.21 primary-amine oxidase primary-amine:oxygen oxidoreductase (deaminating)
1.4.3.4 monoamine oxidase amine:oxygen oxidoreductase (deaminating)
2.4.1.17 glucuronosyltransferase UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)


Proteins

Protein ID name full name