Activated NTRK2 signals through FYN
Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick TJ, Murray SS, Xiao J. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016 Feb;64(2):255–69. doi: 10.1002/glia.22927. PMID: 26449489.; Huang YZ, McNamara JO. Mutual Regulation of Src Family Kinases and the Neurotrophin Receptor TrkB. Journal of Biological Chemistry. 2010 Mar;285(11):8207–17. doi: 10.1074/jbc.m109.091041.; Ahn M, Beacham D, Westenbroek RE, Scheuer T, Catterall WA. Regulation of NaV1.2 Channels by Brain-Derived Neurotrophic Factor, TrkB, and Associated Fyn Kinase. J. Neurosci. 2007 Oct 24;27(43):11533–42. doi: 10.1523/jneurosci.5005-06.2007.; Rajagopal R, Chao MV. A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling. Molecular and Cellular Neuroscience. 2006 Sep;33(1):36–46. doi: 10.1016/j.mcn.2006.06.002.; Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T. Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem. 2003 Mar;10(2):108–15. PMID: 12663749; PMCID: PMC196664.; Narisawa-Saito M, Silva AJ, Yamaguchi T, Hayashi T, Yamamoto T, Nawa H. Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Proc Natl Acad Sci U S A. 1999 Mar 02;96(5):2461–6. PMID: 10051665; PMCID: PMC26807.; Iwasaki Y, Gay B, Wada K, Koizumi S. Association of the Src family tyrosine kinase Fyn with TrkB. J Neurochem. 1998 Jul;71(1):106–11. doi: 10.1046/j.1471-4159.1998.71010106.x. PMID: 9648856.