Retrograde transport at the Trans-Golgi-Network

Chia PZ, Gleeson PA. Membrane tethering. F1000Prime Rep. 2014;6():74. PMID: 25343031; PMCID: PMC4166942.; Sandvig K, Skotland T, van Deurs B, Klokk TI. Retrograde transport of protein toxins through the Golgi apparatus. Histochem Cell Biol. 2013 Sep;140(3):317–26. doi: 10.1007/s00418-013-1111-z. PMID: 23765164.; Bonifacino JS, Hierro A. Transport according to GARP: receiving retrograde cargo at the trans-Golgi network. Trends in Cell Biology. 2011 Mar;21(3):159–67. doi: 10.1016/j.tcb.2010.11.003.; Pfeffer SR. Entry at the trans-Face of the Golgi. Cold Spring Harbor Perspectives in Biology. 2011 Jan 26;3(3):a005272. doi: 10.1101/cshperspect.a005272.; Pérez-Victoria FJ, Bonifacino JS. Dual Roles of the Mammalian GARP Complex in Tethering and SNARE Complex Assembly at the trans -Golgi Network. Molecular and Cellular Biology. 2009 Oct 01;29(19):5251–63. doi: 10.1128/mcb.00495-09.; Johannes L, Popoff V. Tracing the retrograde route in protein trafficking. Cell. 2008 Dec 26;135(7):1175–87. doi: 10.1016/j.cell.2008.12.009. PMID: 19109890.; Pérez-Victoria FJ, Mardones GA, Bonifacino JS. Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol Biol Cell. 2008 Jun;19(6):2350–62. PMID: 18367545; PMCID: PMC2397299.; Bonifacino JS, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nature Reviews Molecular Cell Biology. 2006 Aug;7(8):568–79. doi: 10.1038/nrm1985.; Díaz E, Pfeffer SR. TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell. 1998 May 01;93(3):433–43. doi: 10.1016/s0092-8674(00)81171-x. PMID: 9590177.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.1.-
2.3.1.256 N-terminal methionine Nalpha-acetyltransferase NatC acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nalpha-acetyltransferase
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name