Inhibition of TSC complex formation by PKB

Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004 Aug 15;18(16):1926–45. doi: 10.1101/gad.1212704. PMID: 15314020.; Proud CG. Regulation of mammalian translation factors by nutrients. European Journal of Biochemistry. 2002 Oct 30;269(22):5338–49. doi: 10.1046/j.1432-1033.2002.03292.x.; Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep;4(9):648–57. doi: 10.1038/ncb839. PMID: 12172553.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name