MAPK family signaling cascades

Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012 Apr;92(2):689–737. doi: 10.1152/physrev.00028.2011. PMID: 22535895.; Plotnikov A, Zehorai E, Procaccia S, Seger R. The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2011 Sep;1813(9):1619–33. doi: 10.1016/j.bbamcr.2010.12.012.; Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PMID: 21372320; PMCID: PMC3063353.; Coulombe P, Meloche S. Atypical mitogen-activated protein kinases: Structure, regulation and functions. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Aug;1773(8):1376–87. doi: 10.1016/j.bbamcr.2006.11.001.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Diphosphoric acid,P-(3,7,11-trimethyl-2,6,10-dodecatrienyl) ester

Formula: C15H28O7P2 (382.1310198)

CAS ID: 13058-04-3

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic GMP(1-)

Formula: C10H11N5O7P (344.0396086)

CAS ID:

Palmostatin B

Formula: C23H36O4 (376.2613456)

CAS ID:

Cysmethynil

Formula: C25H32N2O (376.25145019999997)

CAS ID: 851636-83-4



Enzyme

EC Number name full name note
2.3.1.225 protein S-acyltransferase palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.4.19.12 ubiquitinyl hydrolase 1
3.4.26.1 intramembrane prenyl-peptidase Rce1
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name