EGFR downregulation

Marmor MD, Yarden Y. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene. 2004 Mar 15;23(11):2057–70. doi: 10.1038/sj.onc.1207390. PMID: 15021893.; Dikic I. Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans. 2003 Dec;31(Pt 6):1178–81. doi: 10.1042/bst0311178. PMID: 14641021.; Thien CBF, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nature Reviews Molecular Cell Biology. 2001 Apr;2(4):294–307. doi: 10.1038/35067100.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name