IGF1R signaling cascade

Siddle K. Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne). 2012;3():34. PMID: 22649417; PMCID: PMC3355962.; Maki RG. Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol. 2010 Nov 20;28(33):4985–95. PMID: 20975071; PMCID: PMC3039924.; Annunziata M, Granata R, Ghigo E. The IGF system. Acta Diabetol. 2011 Mar;48(1):1–9. doi: 10.1007/s00592-010-0227-z. PMID: 21042815.; Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal. 2010 Jan 21;10():161–77. PMID: 20098959; PMCID: PMC4405166.; Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM. The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res. 2008 Oct 15;14(20):6364–70. doi: 10.1158/1078-0432.ccr-07-4879. PMID: 18927274.; Pavelic J, Matijevic T, Knezevic J. Biological & physiological aspects of action of insulin-like growth factor peptide family. Indian J Med Res. 2007 Apr;125(4):511–22. PMID: 17598937.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name