Aquaporin-mediated transport

Verkman AS. Aquaporins: translating bench research to human disease. J Exp Biol. 2009 Jun;212(Pt 11):1707–15. PMID: 19448080; PMCID: PMC2683014.; Ishibashi K, Koike S, Kondo S, Hara S, Tanaka Y. The role of a group III AQP, AQP11 in intracellular organelle homeostasis. J Med Invest. 2009;56 Suppl():312–7. doi: 10.2152/jmi.56.312. PMID: 20224213.; Carbrey JM, Agre P. Discovery of the aquaporins and development of the field. Handb Exp Pharmacol. 2009;(190):3–28. doi: 10.1007/978-3-540-79885-9_1. PMID: 19096770.; Rojek A, Praetorius J, Frøkiaer J, Nielsen S, Fenton RA. A current view of the mammalian aquaglyceroporins. Annu Rev Physiol. 2008;70():301–27. doi: 10.1146/annurev.physiol.70.113006.100452. PMID: 17961083.; Nielsen S, Kwon T-, Frøkiær J, Agre P. Regulation and dysregulation of aquaporins in water balance disorders*. Journal of Internal Medicine. 2007 Jan;261(1):53–64. doi: 10.1111/j.1365-2796.2006.01760.x.; Gorelick DA, Praetorius J, Tsunenari T, Nielsen S, Agre P. Aquaporin-11: A channel protein lacking apparent transport function expressed in brain. BMC Molecular and Cell Biology. 2006 May 01;7(1):14. doi: 10.1186/1471-2091-7-14.; Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. Disruption of Aquaporin-11 Produces Polycystic Kidneys following Vacuolization of the Proximal Tubule. Molecular and Cellular Biology. 2005 Sep 01;25(17):7770–9. doi: 10.1128/mcb.25.17.7770-7779.2005.; Calamita G. Aquaporins: highways for cells to recycle water with the outside world. Biol Cell. 2005 Jun;97(6):351–3. doi: 10.1042/bc20050017. PMID: 15901243.; Nejsum LN. The renal plumbing system: aquaporin water channels. Cellular and Molecular Life Sciences. 2005 May 28;62(15):1692–706. doi: 10.1007/s00018-005-4549-x.; Itoh T, Rai T, Kuwahara M, Ko SBH, Uchida S, Sasaki S, Ishibashi K. Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochemical and Biophysical Research Communications. 2005 May;330(3):832–8. doi: 10.1016/j.bbrc.2005.03.046.; King LS, Kozono D, Agre P. From structure to disease: the evolving tale of aquaporin biology. Nature Reviews Molecular Cell Biology. 2004 Sep;5(9):687–98. doi: 10.1038/nrm1469.; Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev. 2002 Jan;82(1):205–44. doi: 10.1152/physrev.00024.2001. PMID: 11773613.

Metabolites

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Urea

Formula: CH4N2O (60.0323614)

CAS ID: 57-13-6

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name