Estrogen-dependent gene expression

Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J. Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications. Physiol Rev. 2017 Jul 01;97(3):1045–87. doi: 10.1152/physrev.00024.2016. PMID: 28539435.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; Anbalagan M, Rowan BG. Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3():264–72. doi: 10.1016/j.mce.2015.01.016. PMID: 25597633.; Liu Z, Merkurjev D, Yang F, Li W, Oh S, Friedman MJ, Song X, Zhang F, Ma Q, Ohgi KA, Krones A, Rosenfeld MG. Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell. 2014 Oct 09;159(2):358–73. PMID: 25303530; PMCID: PMC4465761.; Haldosén LA, Zhao C, Dahlman-Wright K. Estrogen receptor beta in breast cancer. Mol Cell Endocrinol. 2014 Jan 25;382(1):665–72. doi: 10.1016/j.mce.2013.08.005. PMID: 23954741.; Magnani L, Lupien M. Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling. Mol Cell Endocrinol. 2014 Jan 25;382(1):633–41. doi: 10.1016/j.mce.2013.04.026. PMID: 23684889.; Hah N, Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and Cellular Endocrinology. 2014 Jan;382(1):652–64. doi: 10.1016/j.mce.2013.06.021.; Liu MH, Cheung E. Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer. Mol Cell Endocrinol. 2014 Jan 25;382(1):624–32. doi: 10.1016/j.mce.2013.09.019. PMID: 24071518.; Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25;51(2):185–99. PMID: 23850489; PMCID: PMC3900250.; Fiorito E, Katika MR, Hurtado A. Cooperating transcription factors mediate the function of estrogen receptor. Chromosoma. 2012 Nov 29;122(1-2):1–12. doi: 10.1007/s00412-012-0392-7.; Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011 Nov 01;25(21):2227–41. PMID: 22056668; PMCID: PMC3219227.; Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet. 2011 Jan;43(1):27–33. PMID: 21151129; PMCID: PMC3024537.; Cheung E, Kraus WL. Genomic analyses of hormone signaling and gene regulation. Annu Rev Physiol. 2010;72():191–218. doi: 10.1146/annurev-physiol-021909-135840. PMID: 20148673.; Welboren WJ, van Driel MA, Janssen-Megens EM, van Heeringen SJ, Sweep FC, Span PN, Stunnenberg HG. ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. EMBO J. 2009 May 20;28(10):1418–28. PMID: 19339991; PMCID: PMC2688537.; Bai Z, Gust R. Breast cancer, estrogen receptor and ligands. Arch Pharm (Weinheim). 2009 Mar;342(3):133–49. doi: 10.1002/ardp.200800174. PMID: 19274700.; Dietz SC, Carroll JS. Interrogating the genome to understand oestrogen-receptor-mediated transcription. Expert Rev Mol Med. 2008 Apr 01;10():e10. doi: 10.1017/s1462399408000653. PMID: 18377699.; Kininis M, Kraus WL. A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal. 2008 Feb 15;6():e005. PMID: 18301785; PMCID: PMC2254333.; Lin Z, Reierstad S, Huang CC, Bulun SE. Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer. Cancer Res. 2007 May 15;67(10):5017–24. doi: 10.1158/0008-5472.can-06-3696. PMID: 17510434.; Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006 Nov;38(11):1289–97. doi: 10.1038/ng1901. PMID: 17013392.; Lin C, Ström A, Vega VB, Li Kong S, Li Yeo A, Thomsen JS, Chan WC, Doray B, Bangarusamy DK, Ramasamy A, Vergara LA, Tang S, Chong A, Bajic VB, Miller LD, Gustafsson J, Liu ET. Discovery of estrogen receptor a target genes and response elements in breast tumor cells. Genome Biology. 2004 Aug 12;5(9):r66. doi: 10.1186/gb-2004-5-9-r66.; Ikeda K, Sato M, Tsutsumi O, Tsuchiya F, Tsuneizumi M, Emi M, Imoto I, Inazawa J, Muramatsu M, Inoue S. Promoter Analysis and Chromosomal Mapping of Human EBAG9 Gene. Biochemical and Biophysical Research Communications. 2000 Jul;273(2):654–60. doi: 10.1006/bbrc.2000.2920.

Metabolites

Progesterone

Formula: C21H30O2 (314.224568)

CAS ID: 57-83-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.13.-
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.7.48 RNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)


Proteins

Protein ID name full name