Signaling by WNT

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. The way Wnt works: Components and mechanism. Growth Factors. 2012 Dec 21;31(1):1–31. doi: 10.3109/08977194.2012.752737.; Willert K, Nusse R. Wnt Proteins. Cold Spring Harbor Perspectives in Biology. 2012 Sep 01;4(9):a007864. doi: 10.1101/cshperspect.a007864.; Rao TP, Kühl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res. 2010 Jun 25;106(12):1798–806. doi: 10.1161/circresaha.110.219840. PMID: 20576942.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Minami Y, Oishi I, Endo M, Nishita M. Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases. Developmental Dynamics. 2009 Jun 15;239(1):1–15. doi: 10.1002/dvdy.21991.; Lai SL, Chien AJ, Moon RT. Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res. 2009 May;19(5):532–45. doi: 10.1038/cr.2009.41. PMID: 19365405.; Schlessinger K, Hall A, Tolwinski N. Wnt signaling pathways meet Rho GTPases. Genes Dev. 2009 Feb 01;23(3):265–77. doi: 10.1101/gad.1760809. PMID: 19204114.; Simons M, Mlodzik M. Planar Cell Polarity Signaling: From Fly Development to Human Disease. Annu. Rev. Genet. 2008 Dec 01;42(1):517–40. doi: 10.1146/annurev.genet.42.110807.091432.; Seifert JR, Mlodzik M. Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet. 2007 Feb;8(2):126–38. doi: 10.1038/nrg2042. PMID: 17230199.; Kimelman D, Xu W. beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene. 2006 Dec 04;25(57):7482–91. doi: 10.1038/sj.onc.1210055. PMID: 17143292.; Kohn AD, Moon RT. Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium. 2005 Sep;38(3-4):439–46. doi: 10.1016/j.ceca.2005.06.022. PMID: 16099039.; Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell. 2003 Sep;5(3):367–77. doi: 10.1016/s1534-5807(03)00266-1. PMID: 12967557.; Kühl M, Sheldahl LC, Park M, Miller JR, Moon RT. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 2000 Jul;16(7):279–83. doi: 10.1016/s0168-9525(00)02028-x. PMID: 10858654.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic GMP(1-)

Formula: C10H11N5O7P (344.0396086)

CAS ID:



Enzyme

EC Number name full name note
3.5.1.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase 3',5'-cyclic-GMP 5'-nucleotidohydrolase
3.4.19.12 ubiquitinyl hydrolase 1
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name