Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Kufer TA, Sansonetti PJ. NLR functions beyond pathogen recognition. Nat Immunol. 2011 Feb;12(2):121–8. doi: 10.1038/ni.1985. PMID: 21245903.; Chen G, Shaw MH, Kim Y, Nuñez G. NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease. Annu. Rev. Pathol. Mech. Dis. 2009 Feb 01;4(1):365–98. doi: 10.1146/annurev.pathol.4.110807.092239.; Proell M, Riedl SJ, Fritz JH, Rojas AM, Schwarzenbacher R. The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences. PLoS ONE. 2008 Apr 30;3(4):e2119. doi: 10.1371/journal.pone.0002119.; Wilmanski JM, Petnicki-Ocwieja T, Kobayashi KS. NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol. 2008 Jan;83(1):13–30. PMID: 17875812; PMCID: PMC3256237.; Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 2005 Aug;26(8):447–54. doi: 10.1016/j.it.2005.06.004. PMID: 15967716.; Kobayashi KS, Eynon EE, Flavell RA. Intracellular debugging. Nat Immunol. 2003 Jul;4(7):652–4. doi: 10.1038/ni0703-652. PMID: 12830145.

Metabolites

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.4.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.4.19.12 ubiquitinyl hydrolase 1


Proteins

Protein ID name full name