Signaling by TGFB family members

Vander Ark A, Cao J, Li X. TGF-ß receptors: In and beyond TGF-ß signaling. Cell Signal. 2018 Dec;52():112–20. doi: 10.1016/j.cellsig.2018.09.002. PMID: 30184463.; Budi EH, Duan D, Derynck R. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 Sep;27(9):658–72. doi: 10.1016/j.tcb.2017.04.005. PMID: 28552280.; Morikawa M, Derynck R, Miyazono K. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May;8(5):a021873. doi: 10.1101/cshperspect.a021873.; Bilandzic M, Stenvers KL. Betaglycan: a multifunctional accessory. Mol Cell Endocrinol. 2011 Jun 06;339(1-2):180–9. doi: 10.1016/j.mce.2011.04.014. PMID: 21550381.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp Biol Med (Maywood). 2006 May;231(5):534–44. doi: 10.1177/153537020623100507. PMID: 16636301.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase


Proteins

Protein ID name full name