Toll Like Receptor 4 (TLR4) Cascade
Zughaier SM, Zimmer SM, Datta A, Carlson RW, Stephens DS. Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins. Infect Immun. 2005 May;73(5):2940–50. doi: 10.1128/iai.73.5.2940-2950.2005.; Sacre SM, Andreakos E, Feldmann M, Foxwell BM. Endotoxin signaling in human macrophages: signaling via an alternate mechanism. Journal of Endotoxin Research. 2004 Dec;10(6):445–52. doi: 10.1177/09680519040100060101.; Fitzgerald KA, Rowe DC, Golenbock DT. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec;6(15):1361–7. doi: 10.1016/j.micinf.2004.08.015. PMID: 15596121.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.-.- | |||
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.7.11.10 | IkappaB kinase | ATP:[IkappaB protein] phosphotransferase |
Proteins
| Protein ID | name | full name |
|---|