TCR signaling

Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol. 2003 Jul;3(7):544–56. doi: 10.1038/nri1131. PMID: 12876557.; van Leeuwen JE, Samelson LE. T cell antigen-receptor signal transduction. Curr Opin Immunol. 1999 Jun;11(3):242–8. doi: 10.1016/s0952-7915(99)80040-5. PMID: 10375551.; Rudd CE. Adaptors and molecular scaffolds in immune cell signaling. Cell. 1999 Jan 08;96(1):5–8. doi: 10.1016/s0092-8674(00)80953-8. PMID: 9989491.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase


Proteins

Protein ID name full name