TRAF6-mediated induction of TAK1 complex within TLR4 complex

Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 03;461(7260):114–9. PMID: 19675569; PMCID: PMC2747300.; Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y. TRAF6 Autoubiquitination-Independent Activation of the NF?B and MAPK Pathways in Response to IL-1 and RANKL. PLoS ONE. 2008 Dec 29;3(12):e4064. doi: 10.1371/journal.pone.0004064.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)


Proteins

Protein ID name full name