RAB GEFs exchange GTP for GDP on RABs
Ishida M, E Oguchi M, Fukuda M. Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases. Cell Struct Funct. 2016 Jul 09;41(2):61–79. doi: 10.1247/csf.16008. PMID: 27246931.; Palsuledesai CC, Distefano MD. Protein prenylation: enzymes, therapeutics, and biotechnology applications. ACS Chem Biol. 2015 Jan 16;10(1):51–62. PMID: 25402849; PMCID: PMC4301080.; Wandinger-Ness A, Zerial M. Rab Proteins and the Compartmentalization of the Endosomal System. Cold Spring Harbor Perspectives in Biology. 2014 Oct 23;6(11):a022616. doi: 10.1101/cshperspect.a022616.; Gavriljuk K, Itzen A, Goody RS, Gerwert K, Kötting C. Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13380–5. PMID: 23898197; PMCID: PMC3746908.; Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269–309. doi: 10.1152/physrev.00003.2012. PMID: 23303910.; Gutkowska M, Swiezewska E. Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein. Molecular Membrane Biology. 2012 Jun 14;29(7):243–56. doi: 10.3109/09687688.2012.693211.; Frasa MAM, Koessmeier KT, Ahmadian MR, Braga VMM. Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nature Reviews Molecular Cell Biology. 2012 Jan 18;13(2):67–73. doi: 10.1038/nrm3267.; Marat AL, Dokainish H, McPherson PS. DENN Domain Proteins: Regulators of Rab GTPases. Journal of Biological Chemistry. 2011 Apr;286(16):13791–800. doi: 10.1074/jbc.r110.217067.; Fukuda M. TBC proteins: GAPs for mammalian small GTPase Rab? Biosci Rep. 2011 Jun;31(3):159–68. doi: 10.1042/bsr20100112. PMID: 21250943.; Barr F, Lambright DG. Rab GEFs and GAPs. Current Opinion in Cell Biology. 2010 Aug;22(4):461–70. doi: 10.1016/j.ceb.2010.04.007.; Wu YW, Oesterlin LK, Tan KT, Waldmann H, Alexandrov K, Goody RS. Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol. 2010 Jul;6(7):534–40. doi: 10.1038/nchembio.386. PMID: 20512138.; Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nature Reviews Molecular Cell Biology. 2009 Jul 15;10(8):513–25. doi: 10.1038/nrm2728.; Baron RA, Seabra MC. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochem J. 2008 Oct 01;415(1):67–75. doi: 10.1042/bj20080662. PMID: 18532927.; Pan X, Eathiraj S, Munson M, Lambright DG. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature. 2006 Jul 20;442(7100):303–6. doi: 10.1038/nature04847. PMID: 16855591.; Sivars U, Aivazian D, Pfeffer SR. Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature. 2003 Oct 23;425(6960):856–9. doi: 10.1038/nature02057. PMID: 14574414.; Seabra MC. Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab. J Biol Chem. 1996 Jun 14;271(24):14398–404. doi: 10.1074/jbc.271.24.14398. PMID: 8662963.; Shen F, Seabra MC. Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein. J Biol Chem. 1996 Feb 16;271(7):3692–8. doi: 10.1074/jbc.271.7.3692. PMID: 8631982.; Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc. Natl. Acad. Sci. U.S.A. 1994 Dec 06;91(25):11963–7. doi: 10.1073/pnas.91.25.11963.; Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra MC, Zerial M. Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. The EMBO Journal. 1994 Nov;13(22):5262–73. doi: 10.1002/j.1460-2075.1994.tb06860.x.; Soldati T, Shapiro AD, Svejstrup AB, Pfeffer SR. Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange. Nature. 1994 May 05;369(6475):76–8. doi: 10.1038/369076a0. PMID: 8164745.; Ullrich O, Stenmark H, Alexandrov K, Huber LA, Kaibuchi K, Sasaki T, Takai Y, Zerial M. Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. Journal of Biological Chemistry. 1993 Aug;268(24):18143–50. doi: 10.1016/s0021-9258(17)46822-0.; Chavrier P, Gorvel JP, Stelzer E, Simons K, Gruenberg J, Zerial M. Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Nature. 1991 Oct 24;353(6346):769–72. doi: 10.1038/353769a0. PMID: 1944536.