Nucleotide metabolism

Welin M, Nordlund P. Understanding specificity in metabolic pathways—Structural biology of human nucleotide metabolism. Biochemical and Biophysical Research Communications. 2010 May;396(1):157–63. doi: 10.1016/j.bbrc.2010.04.054.; Hyde JE. Targeting purine and pyrimidine metabolism in human apicomplexan parasites. Curr Drug Targets. 2007 Jan;8(1):31–47. PMID: 17266529; PMCID: PMC2720675.; Rudolph FB. The biochemistry and physiology of nucleotides. J Nutr. 1994 Jan;124(1 Suppl):124S–127S. doi: 10.1093/jn/124.suppl_1.124s. PMID: 8283301.

Metabolites

5,6-Dihydrouracil

Formula: C4H6N2O2 (114.04292559999999)

CAS ID: 504-07-4

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Molybdopterin

Formula: C10H14N5O6PS2 (395.01231140000004)

CAS ID: 220399-50-8

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pseudouridine

Formula: C9H12N2O6 (244.0695332)

CAS ID: 1445-07-4

Pseudouridine 5'-phosphate

Formula: C9H13N2O9P (324.03586580000007)

CAS ID: 1157-60-4

Thymidine

Formula: C10H14N2O5 (242.09026740000002)

CAS ID: 50-89-5

Thymine

Formula: C5H6N2O2 (126.04292559999999)

CAS ID: 65-71-4

Ubiquinone-10

Formula: C59H90O4 (862.683874)

CAS ID: 303-98-0

Uracil

Formula: C4H4N2O2 (112.02727639999999)

CAS ID: 66-22-8

Urate

Formula: C5H4N4O3 (168.0283394)

CAS ID: 69-93-2

Xanthine

Formula: C5H4N4O2 (152.0334244)

CAS ID: 69-89-6

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

QH(2)

Formula: C14H20O4 (252.136152)

CAS ID: 52590-98-4

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

Formula: C9H13N4O8P (336.0470988)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

IDP(3-)

Formula: C10H11N4O11P2 (424.98995759999997)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

8-oxo-dGTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID:

2-hydroxy-dATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

beta-D-fructofuranose 1,6-bisphosphate(4-)

Formula: C6H10O12P2 (335.96475200000003)

CAS ID: 488-69-7

P(1),P(6)-bis(5'-adenosyl)hexaphosphate(6-)

Formula: C20H24N10O25P6 (989.9339834)

CAS ID:

2'-deoxyguanosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID: 7720-24-3

dTMP(2-)

Formula: C10H13N2O8P (320.0409508)

CAS ID: 14057-65-9

methylammonium

Formula: CH6N (32.0500216)

CAS ID: 17000-00-9



Enzyme

EC Number name full name note
2.4.2.8 hypoxanthine phosphoribosyltransferase IMP:diphosphate phospho-D-ribosyltransferase
2.7.13.3 histidine kinase ATP:protein-L-histidine N-phosphotransferase
2.7.4.14 UMP/CMP kinase ATP:CMP(UMP) phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase


Proteins

Protein ID name full name