IRE1alpha activates chaperones

Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008 May;29(3):317–33. PMID: 18436705; PMCID: PMC2528859.; Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev. 2008 Feb;29(1):42–61. doi: 10.1210/er.2007-0015. PMID: 18048764.; Schröder M. Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences. 2007 Nov 26;65(6):862–94. doi: 10.1007/s00018-007-7383-5.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.26.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name
O94537 ire1 Sensor for unfolded proteins in the ER ire1