Ribosomal scanning and start codon recognition

Pestova TV, Borukhov SI, Hellen CU. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature. 1998 Aug 27;394(6696):854–9. doi: 10.1038/29703. PMID: 9732867.; Kozak M. Evaluation of the 'scanning model' for initiation of protein synthesis in eucaryotes. Cell. 1980 Nov;22(1 Pt 1):7–8. doi: 10.1016/0092-8674(80)90148-8. PMID: 7000367.; Benne R, Hershey JW. The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. Journal of Biological Chemistry. 1978 May;253(9):3078–87. doi: 10.1016/s0021-9258(17)40805-2.; Trachsel H, Erni B, Schreier MH, Staehelin T. Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. J Mol Biol. 1977 Nov;116(4):755–67. doi: 10.1016/0022-2836(77)90269-8. PMID: 592399.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.5.3 protein-synthesizing GTPase GTP phosphohydrolase (mRNA-translation-assisting)


Proteins

Protein ID name full name
Q09130 tif213 Eukaryotic translation initiation factor 2 subunit gamma