Mitotic G2-G2/M phases

Wang G, Jiang Q, Zhang C. The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. J Cell Sci. 2014 Oct 01;127(Pt 19):4111–22. doi: 10.1242/jcs.151753. PMID: 25128564.; Bruinsma W, Raaijmakers JA, Medema RH. Switching Polo-like kinase-1 on and off in time and space. Trends Biochem Sci. 2012 Dec;37(12):534–42. doi: 10.1016/j.tibs.2012.09.005. PMID: 23141205.; O'Farrell PH. Triggering the all-or-nothing switch into mitosis. Trends in Cell Biology. 2001 Dec 01;11(12):512–9. doi: 10.1016/s0962-8924(01)02142-0.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methanol

Formula: CH4O (32.0262134)

CAS ID: 67-56-1

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
3.1.1.89 protein phosphatase methylesterase-1 [phosphatase 2A protein]-leucine ester acylhydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name
P23748 MIH1 M-phase inducer phosphatase
P32562 CDC5 Cell cycle serine/threonine-protein kinase CDC5/MSD2
P32944 SWE1 Mitosis inhibitor protein kinase SWE1
P38796 PPE1 Protein phosphatase methylesterase 1
P38991 IPL1 Aurora kinase
Q04081 PPM1 Leucine carboxyl methyltransferase 1