Signaling by Interleukins

Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor ß, and TNF-a: Receptors, functions, and roles in diseases. Journal of Allergy and Clinical Immunology. 2016 Oct;138(4):984–1010. doi: 10.1016/j.jaci.2016.06.033.; Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27():519–50. doi: 10.1146/annurev.immunol.021908.132612. PMID: 19302047.; Vosshenrich CA, Di Santo JP. Interleukin signaling. Curr Biol. 2002 Nov 19;12(22):R760–3. doi: 10.1016/s0960-9822(02)01286-1. PMID: 12445398.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)


Proteins

Protein ID name full name
P32485 HOG1 Mitogen-activated protein kinase HOG1
P38070 YPK3 Serine/threonine-protein kinase YPK3
Q00772 SLT2 Mitogen-activated protein kinase SLT2/MPK1