Depyrimidination

Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.

Metabolites

4,6-Diamino-5-formamidopyrimidine

Formula: C5H7N5O (153.0650572)

CAS ID: 5122-36-1

5,6-Dihydrouracil

Formula: C4H6N2O2 (114.04292559999999)

CAS ID: 504-07-4

Uracil

Formula: C4H4N2O2 (112.02727639999999)

CAS ID: 66-22-8

Thymine glycol

Formula: C5H8N2O4 (160.0484048)

CAS ID: 2943-56-8

5-Hydroxyuracil

Formula: C4H4N2O3 (128.0221914)

CAS ID: 20636-41-3

cytosine glycol

Formula: C4H7N3O3 (145.0487392)

CAS ID: 13484-98-5

2,6-diamino-5-formamido-4-hydroxypyrimidine

Formula: C5H7N5O2 (169.05997220000003)

CAS ID: 133310-38-0



Enzyme

EC Number name full name note
3.2.2.-
3.2.2.27 uracil-DNA glycosylase uracil-DNA deoxyribohydrolase (uracil-releasing)
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase


Proteins

Protein ID name full name
P12887 UNG1 Uracil-DNA glycosylase
P53397 OGG1 N-glycosylase/DNA lyase
Q08214 NTG2 Endonuclease III homolog 2