Gap junction trafficking and regulation

Piehl M, Lehmann C, Gumpert A, Denizot JP, Segretain D, Falk MM. Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol Biol Cell. 2007 Feb;18(2):337–47. PMID: 17108328; PMCID: PMC1783799.; Berthoud VM, Minogue PJ, Laing JG, Beyer EC. Pathways for degradation of connexins and gap junctions. Cardiovasc Res. 2004 May 01;62(2):256–67. doi: 10.1016/j.cardiores.2003.12.021. PMID: 15094346.; Segretain D, Falk MM. Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2004 Mar;1662(1-2):3–21. doi: 10.1016/j.bbamem.2004.01.007.; Hervé J, Bourmeyster N, Sarrouilhe D. Diversity in protein–protein interactions of connexins: emerging roles. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2004 Mar;1662(1-2):22–41. doi: 10.1016/j.bbamem.2003.10.022.; Bruzzone R. Learning the language of cell-cell communication through connexin channels. Genome Biology. 2001 Oct 15;2(11):reports4027.1. doi: 10.1186/gb-2001-2-11-reports4027.; Kelsell DP, Dunlop J, Hodgins MB. Human diseases: clues to cracking the connexin code? Trends Cell Biol. 2001 Jan;11(1):2–6. doi: 10.1016/s0962-8924(00)01866-3. PMID: 11146276.; Simon AM, Goodenough DA. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 1998 Dec;8(12):477–83. doi: 10.1016/s0962-8924(98)01372-5. PMID: 9861669.; Bruzzone R, White TW, Paul DL. Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling. European Journal of Biochemistry. 1996 May;238(1):1–27. doi: 10.1111/j.1432-1033.1996.0001q.x.; Laird DW, Castillo M, Kasprzak L. Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells. J Cell Biol. 1995 Dec;131(5):1193–203. PMID: 8522583; PMCID: PMC2120642.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)


Proteins

Protein ID name full name