CDK-mediated phosphorylation and removal of Cdc6

Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem. 2002;71():333–74. doi: 10.1146/annurev.biochem.71.110601.135425. PMID: 12045100.; Méndez J, Stillman B. Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis. Molecular and Cellular Biology. 2000 Nov 01;20(22):8602–12. doi: 10.1128/mcb.20.22.8602-8612.2000.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase


Proteins

Protein ID name full name