Aflatoxin activation and detoxification
Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention. Oncol Lett. 2013 Apr;5(4):1087–92. PMID: 23599745; PMCID: PMC3629261.; Wu Q, Jezkova A, Yuan Z, Pavlikova L, Dohnal V, Kuca K. Biological degradation of aflatoxins. Drug Metab Rev. 2009;41(1):1–7. doi: 10.1080/03602530802563850. PMID: 19514968.; Wild CP, Turner PC. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis. 2002 Nov;17(6):471–81. doi: 10.1093/mutage/17.6.471. PMID: 12435844.; Guengerich FP, Johnson WW, Shimada T, Ueng Y, Yamazaki H, Langouët S. Activation and detoxication of aflatoxin B1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1998 Jun;402(1-2):121–8. doi: 10.1016/s0027-5107(97)00289-3.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.n11 | |||
| 1.1.1.2 | alcohol dehydrogenase (NADP+) | alcohol:NADP+ oxidoreductase | |
| 1.14.14.1 | unspecific monooxygenase | substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 2.3.2.2 | gamma-glutamyltransferase | (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase | |
| 2.5.1.18 | glutathione transferase | RX:glutathione R-transferase | |
| 3.4.13.19 | membrane dipeptidase | ||
| 3.4.19.13 | glutathione gamma-glutamate hydrolase | ||
| 3.4.19.14 | leukotriene-C4 hydrolase | ||
| 3.5.1.114 | N-acyl-aromatic-L-amino acid amidohydrolase | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | |
| 3.5.1.14 | N-acyl-aliphatic-L-amino acid amidohydrolase | N-acyl-aliphatic-L-amino acid amidohydrolase (carboxylate-forming) | |
| 3.5.2.6 | beta-lactamase | beta-lactam hydrolase | |
| 4.2.1.152 | hydroperoxy icosatetraenoate dehydratase | hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming) |
Proteins
| Protein ID | name | full name |
|---|