Regulation of TNFR1 signaling

Harhaj EW, Dixit VM. Regulation of NF-?B by deubiquitinases. Immunological Reviews. 2012 Mar;246(1):107–24. doi: 10.1111/j.1600-065x.2012.01100.x.; Zhang JY, Adams AE, Ridky TW, Tao S, Khavari PA. Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. Cancer Res. 2007 Apr 15;67(8):3827–34. PMID: 17440097; PMCID: PMC2239246.; Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007 Mar 01;26(10):1385–97. doi: 10.1038/sj.onc.1209945. PMID: 16953224.; Yang Y, Yu X. Regulation of apoptosis: the ubiquitous way. FASEB J. 2003 May;17(8):790–9. doi: 10.1096/fj.02-0654rev. PMID: 12724336.; Matsuzawa A, Ichijo H. Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1. Journal of Biochemistry. 2001 Jul 01;130(1):1–8. doi: 10.1093/oxfordjournals.jbchem.a002947.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.31 RBR-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
3.4.19.12 ubiquitinyl hydrolase 1
3.4.22.61 caspase-8


Proteins

Protein ID name full name