Intrinsic Pathway for Apoptosis

Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G, Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene. 2004 Apr 12;23(16):2861–74. doi: 10.1038/sj.onc.1207523. PMID: 15077149.; Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003 Nov 24;22(53):8590–607. doi: 10.1038/sj.onc.1207102. PMID: 14634621.; Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev. 2003 Oct 15;17(20):2481–95. doi: 10.1101/gad.1126903. PMID: 14561771.; Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nature Reviews Molecular Cell Biology. 2002 Jun;3(6):401–10. doi: 10.1038/nrm830.; Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001 Nov 15;15(22):2922–33. PMID: 11711427.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.97 glycylpeptide N-tetradecanoyltransferase tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.4.21.79 granzyme B
3.4.22.56 caspase-3
3.4.22.60 caspase-7
3.4.22.61 caspase-8
3.4.22.62 caspase-9
4.2.1.109 methylthioribulose 1-phosphate dehydratase S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]


Proteins

Protein ID name full name