Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

Benedetti MS. Biotransformation of xenobiotics by amine oxidases. Fundam Clin Pharmacol. 2001 Apr;15(2):75–84. doi: 10.1046/j.1472-8206.2001.00011.x. PMID: 11468017.; Beedham C. The role of non—P450 enzymes in drug oxidation. International Journal of Clinical Pharmacy. 1997 Dec;19(6):255–63. doi: 10.1023/a:1008668913093.

Metabolites

4-Hydroxyphenylacetaldehyde

Formula: C8H8O2 (136.0524268)

CAS ID: 7339-87-9

5-Hydroxyindoleacetaldehyde

Formula: C10H9NO2 (175.0633254)

CAS ID: 1892-21-3

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Phenethylamine

Formula: C8H11N (121.0891446)

CAS ID: 64-04-0

Phenylacetaldehyde

Formula: C8H8O (120.0575118)

CAS ID: 122-78-1

Tyramine

Formula: C8H11NO (137.0840596)

CAS ID: 51-67-2

serotonin(1+)

Formula: C10H13N2O (177.1027828)

CAS ID:



Enzyme

EC Number name full name note
1.4.3.21 primary-amine oxidase primary-amine:oxygen oxidoreductase (deaminating)
1.4.3.4 monoamine oxidase amine:oxygen oxidoreductase (deaminating)


Proteins

Protein ID name full name