Synthesis of PA

Prasad SS, Garg A, Agarwal AK. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Journal of Lipid Research. 2011 Mar;52(3):451–62. doi: 10.1194/jlr.m007575.; Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2ß) and Comparison with the Other cPLA2 Isoforms. Journal of Biological Chemistry. 2010 Nov;285(46):36100–11. doi: 10.1074/jbc.m110.165647.; Shindou H, Shimizu T. Acyl-CoA:Lysophospholipid Acyltransferases. Journal of Biological Chemistry. 2009 Jan;284(1):1–5. doi: 10.1074/jbc.r800046200.; Cao J, Li J, Li D, Tobin JF, Gimeno RE. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proc. Natl. Acad. Sci. U.S.A. 2006 Dec 26;103(52):19695–700. doi: 10.1073/pnas.0609140103.; Singer AG, Ghomashchi F, Le Calvez C, Bollinger J, Bezzine S, Rouault M, Sadilek M, Nguyen E, Lazdunski M, Lambeau G, Gelb MH. Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2. Journal of Biological Chemistry. 2002 Dec;277(50):48535–49. doi: 10.1074/jbc.m205855200.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Glycerol 1-myristate

Formula: C17H34O4 (302.2456964)

CAS ID: 27214-38-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
3.1.1.-
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
1.1.5.3 glycerol-3-phosphate dehydrogenase sn-glycerol 3-phosphate:quinone oxidoreductase
2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
2.3.1.42 glycerone-phosphate O-acyltransferase acyl-CoA:glycerone-phosphate O-acyltransferase
2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
3.1.1.111 phosphatidylserine sn-1 acylhydrolase 3-sn-phosphatidyl-L-serine sn-1 acylhydrolase
3.1.1.118 phospholipid sn-1 acylhydrolase phospholipid sn-1 acylhydrolase
3.1.1.3 triacylglycerol lipase triacylglycerol acylhydrolase
3.1.1.32 phospholipase A1 phosphatidylcholine 1-acylhydrolase
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.3.2 acid phosphatase phosphate-monoester phosphohydrolase (acid optimum)


Proteins

Protein ID name full name