Interleukin-6 signaling

Rothaug M, Becker-Pauly C, Rose-John S. The role of interleukin-6 signaling in nervous tissue. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Jun;1863(6):1218–27. doi: 10.1016/j.bbamcr.2016.03.018.; Wolf J, Rose-John S, Garbers C. Interleukin-6 and its receptors: a highly regulated and dynamic system. Cytokine. 2014 Nov;70(1):11–20. doi: 10.1016/j.cyto.2014.05.024. PMID: 24986424.; Kopf M, Bachmann MF, Marsland BJ. Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov. 2010 Sep;9(9):703–18. doi: 10.1038/nrd2805. PMID: 20811382.; Kishimoto T. IL-6: from its discovery to clinical applications. International Immunology. 2010 Apr 21;22(5):347–52. doi: 10.1093/intimm/dxq030.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name