Growth hormone receptor signaling

Brooks AJ, Waters MJ. The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol. 2010 Sep;6(9):515–25. doi: 10.1038/nrendo.2010.123. PMID: 20664532.; Deng L, He K, Wang X, Yang N, Thangavel C, Jiang J, Fuchs SY, Frank SJ. Determinants of growth hormone receptor down-regulation. Mol Endocrinol. 2007 Jul;21(7):1537–51. doi: 10.1210/me.2007-0138. PMID: 17488973.; Rowland JE, Lichanska AM, Kerr LM, White M, d’Aniello EM, Maher SL, Brown R, Teasdale RD, Noakes PG, Waters MJ. In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts. Molecular and Cellular Biology. 2005 Jan 01;25(1):66–77. doi: 10.1128/mcb.25.1.66-77.2005.; Postel-Vinay MC, Finidori J. Growth hormone receptor: structure and signal transduction. Eur J Endocrinol. 1995 Dec;133(6):654–9. doi: 10.1530/eje.0.1330654. PMID: 8548048.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.24.86 ADAM 17 endopeptidase


Proteins

Protein ID name full name