Interleukin-12 signaling

Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev. 2003 Oct;14(5):361–8. doi: 10.1016/s1359-6101(03)00043-1. PMID: 12948519.; Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003 Feb;3(2):133–46. doi: 10.1038/nri1001. PMID: 12563297.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.8.-.-
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
1.20.4.2 methylarsonate reductase glutathione:methylarsonate oxidoreductase
1.8.5.1 glutathione dehydrogenase (ascorbate) glutathione:dehydroascorbate oxidoreductase
2.2.1.2 transaldolase sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
2.5.1.18 glutathione transferase RX:glutathione R-transferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)
4.2.1.1 carbonic anhydrase carbonic acid hydro-lyase (carbon-dioxide-forming)
4.2.1.69 cyanamide hydratase urea hydro-lyase (cyanamide-forming)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase
5.3.2.1 phenylpyruvate tautomerase phenylpyruvate keto---enol-isomerase
5.3.3.12 L-dopachrome isomerase L-dopachrome keto-enol isomerase
5.3.4.1 protein disulfide-isomerase Protein disulfide-isomerase


Proteins

Protein ID name full name