TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Doidge R, Mittal S, Aslam A, Winkler GS. The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex. PLoS ONE. 2012 Dec 07;7(12):e51331. doi: 10.1371/journal.pone.0051331.; Ezzeddine N, Chen CA, Shyu A. Evidence Providing New Insights into TOB-Promoted Deadenylation and Supporting a Link between TOB's Deadenylation-Enhancing and Antiproliferative Activities. Molecular and Cellular Biology. 2012 Mar 01;32(6):1089–98. doi: 10.1128/mcb.06370-11.; Chang J, Cizmecioglu O, Hoffmann I, Rhee K. PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. EMBO J. 2010 Jul 21;29(14):2395–406. PMID: 20531387; PMCID: PMC2910268.; Krause A, Hoffmann I. Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication. PLoS ONE. 2010 Mar 24;5(3):e9849. doi: 10.1371/journal.pone.0009849.; Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F. Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex. Journal of Biological Chemistry. 2009 May;284(19):13244–55. doi: 10.1074/jbc.m809250200.; Mauxion F, Faux C, Séraphin B. The BTG2 protein is a general activator of mRNA deadenylation. EMBO J. 2008 Apr 09;27(7):1039–48. PMID: 18337750; PMCID: PMC2323266.; Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. Oncogene. 2007 Feb 22;26(8):1110–21. doi: 10.1038/sj.onc.1210148. PMID: 17146433.; Syed N, Smith P, Sullivan A, Spender LC, Dyer M, Karran L, O'Nions J, Allday M, Hoffmann I, Crawford D, Griffin B, Farrell PJ, Crook T. Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies. Blood. 2006 Jan 01;107(1):250–6. doi: 10.1182/blood-2005-03-1194. PMID: 16160013.; Jen KY, Cheung VG. Identification of novel p53 target genes in ionizing radiation response. Cancer Res. 2005 Sep 01;65(17):7666–73. doi: 10.1158/0008-5472.can-05-1039. PMID: 16140933.; Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene. 2004 Apr 08;23(15):2658–63. doi: 10.1038/sj.onc.1207425. PMID: 14968113.; Burns TF, Fei P, Scata KA, Dicker DT, El-Deiry WS. Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells. Molecular and Cellular Biology. 2003 Aug 01;23(16):5556–71. doi: 10.1128/mcb.23.16.5556-5571.2003.; Rozenfeld-Granot G, Krishnamurthy J, Kannan K, Toren A, Amariglio N, Givol D, Rechavi G. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1. Oncogene. 2002 Feb 27;21(10):1469–76. doi: 10.1038/sj.onc.1205218. PMID: 11896574.; Duriez C, Falette N, Audoynaud C, Moyret-Lalle C, Bensaad K, Courtois S, Wang Q, Soussi T, Puisieux A. The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene. Gene. 2002 Jan 09;282(1-2):207–14. doi: 10.1016/s0378-1119(01)00825-3. PMID: 11814693.; Rouault JP, Prévôt D, Berthet C, Birot AM, Billaud M, Magaud JP, Corbo L. Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex. J Biol Chem. 1998 Aug 28;273(35):22563–9. doi: 10.1074/jbc.273.35.22563. PMID: 9712883.; Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 21;95(15):8835–40. doi: 10.1073/pnas.95.15.8835.; Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814–25. PMID: 9184226; PMCID: PMC1169890.; Rouault JP, Falette N, Guéhenneux F, Guillot C, Rimokh R, Wang Q, Berthet C, Moyret-Lalle C, Savatier P, Pain B, Shaw P, Berger R, Samarut J, Magaud JP, Ozturk M, Samarut C, Puisieux A. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet. 1996 Dec;14(4):482–6. doi: 10.1038/ng1296-482. PMID: 8944033.