Mitotic G2-G2/M phases

Wang G, Jiang Q, Zhang C. The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. J Cell Sci. 2014 Oct 01;127(Pt 19):4111–22. doi: 10.1242/jcs.151753. PMID: 25128564.; Bruinsma W, Raaijmakers JA, Medema RH. Switching Polo-like kinase-1 on and off in time and space. Trends Biochem Sci. 2012 Dec;37(12):534–42. doi: 10.1016/j.tibs.2012.09.005. PMID: 23141205.; O'Farrell PH. Triggering the all-or-nothing switch into mitosis. Trends in Cell Biology. 2001 Dec 01;11(12):512–9. doi: 10.1016/s0962-8924(01)02142-0.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methanol

Formula: CH4O (32.0262134)

CAS ID: 67-56-1

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.32 cullin-RING-type E3 NEDD8 transferase [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
3.1.1.89 protein phosphatase methylesterase-1 [phosphatase 2A protein]-leucine ester acylhydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.1.3.53 [myosin-light-chain] phosphatase [myosin-light-chain]-phosphate phosphohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name