MAPK6/MAPK4 signaling

Kostenko S, Dumitriu G, Moens U. Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal. 2012 Jul 16;7(1):9. PMID: 22800433; PMCID: PMC3419095.; Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May;122(5):1869–80. PMID: 22505454; PMCID: PMC3336992.; Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PMID: 21372320; PMCID: PMC3063353.; Déléris P, Trost M, Topisirovic I, Tanguay P, Borden KLB, Thibault P, Meloche S. Activation Loop Phosphorylation of ERK3/ERK4 by Group I p21-activated Kinases (PAKs) Defines a Novel PAK-ERK3/4-MAPK-activated Protein Kinase 5 Signaling Pathway. Journal of Biological Chemistry. 2011 Feb;286(8):6470–8. doi: 10.1074/jbc.m110.181529.; Myant K, Sansom OJ. More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer. Mol Cell. 2011 Feb 18;41(4):369–70. doi: 10.1016/j.molcel.2011.01.028. PMID: 21329875.; Kostenko S, Shiryaev A, Dumitriu G, Gerits N, Moens U. Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5. Journal of Receptors and Signal Transduction. 2010 Sep 18;31(1):1–9. doi: 10.3109/10799893.2010.515593.; Kostenko S, Johannessen M, Moens U. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Cell Signal. 2009 May;21(5):712–8. doi: 10.1016/j.cellsig.2009.01.009. PMID: 19166925.; Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression. Molecular and Cellular Biology. 2008 Oct 01;28(19):5937–50. doi: 10.1128/mcb.00579-08.; Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol. 2008 Dec;217(3):778–88. doi: 10.1002/jcp.21560. PMID: 18720373.; Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee LY, Tsai SY, Tsai MJ. Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 2008 Jul 01;68(13):5460–8. PMID: 18593949; PMCID: PMC2826835.; Perander M, Aberg E, Johansen B, Dreyer B, Guldvik IJ, Outzen H, Keyse SM, Seternes OM. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. Biochem J. 2008 May 01;411(3):613–22. doi: 10.1042/bj20071369. PMID: 18248330.; Gerits N, Mikalsen T, Kostenko S, Shiryaev A, Johannessen M, Moens U. Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5. Journal of Biological Chemistry. 2007 Dec;282(51):37232–43. doi: 10.1074/jbc.m704873200.; Coulombe P, Meloche S. Atypical mitogen-activated protein kinases: Structure, regulation and functions. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Aug;1773(8):1376–87. doi: 10.1016/j.bbamcr.2006.11.001.; Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche S. N-Terminal Ubiquitination of Extracellular Signal-Regulated Kinase 3 and p21 Directs Their Degradation by the Proteasome. Molecular and Cellular Biology. 2004 Jul 01;24(14):6140–50. doi: 10.1128/mcb.24.14.6140-6150.2004.; Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S. Rapid Turnover of Extracellular Signal-Regulated Kinase 3 by the Ubiquitin-Proteasome Pathway Defines a Novel Paradigm of Mitogen-Activated Protein Kinase Regulation during Cellular Differentiation. Molecular and Cellular Biology. 2003 Jul 01;23(13):4542–58. doi: 10.1128/mcb.23.13.4542-4558.2003.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.6.4.13 RNA helicase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name