Signaling by NOTCH4
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PMID: 26801977; PMCID: PMC5167360.; Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity. Cell Rep. 2015 Sep 29;12(12):1968–77. PMID: 26387946; PMCID: PMC4594158.; Ramakrishnan G, Davaakhuu G, Chung WC, Zhu H, Rana A, Filipovic A, Green AR, Atfi A, Pannuti A, Miele L, Tzivion G. AKT and 14-3-3 Regulate Notch4 Nuclear Localization. Scientific Reports. 2015 Mar 05;5(1):8782. doi: 10.1038/srep08782.; Qian C, Liu F, Ye B, Zhang X, Liang Y, Yao J. Notch4 promotes gastric cancer growth through activation of Wnt1/ß-catenin signaling. Molecular and Cellular Biochemistry. 2014 Dec 16;401(1-2):165–74. doi: 10.1007/s11010-014-2304-z.; Li Y, Wu S, Pu J, Huang X, Zhang P. Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-ß signalling pathway. Immunology. 2014 Dec 08;144(1):127–38. doi: 10.1111/imm.12357.; James AC, Szot JO, Iyer K, Major JA, Pursglove SE, Chapman G, Dunwoodie SL. Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2014 Jul;1843(7):1272–84. doi: 10.1016/j.bbamcr.2014.03.015.; Lai P, Tsai C, Tseng M. Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes. Biochemical and Biophysical Research Communications. 2013 Jan;430(3):1132–9. doi: 10.1016/j.bbrc.2012.12.024.; Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE. Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors. PLoS ONE. 2010 Feb 08;5(2):e9094. doi: 10.1371/journal.pone.0009094.; Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R. Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis. Oncogene. 2009 Jan 15;28(2):219–30. PMID: 18836481; PMCID: PMC2794555.; Tang Y, Urs S, Liaw L. Hairy-Related Transcription Factors Inhibit Notch-Induced Smooth Muscle a-Actin Expression by Interfering With Notch Intracellular Domain/CBF-1 Complex Interaction With the CBF-1–Binding Site. Circulation Research. 2008 Mar 28;102(6):661–8. doi: 10.1161/circresaha.107.165134.; Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest. 2007 Nov;117(11):3369–82. PMID: 17948123; PMCID: PMC2030453.; Raafat A, Zoltan-Jones A, Strizzi L, Bargo S, Kimura K, Salomon D, Callahan R. Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis. Oncogene. 2007 Feb 01;26(5):662–72. doi: 10.1038/sj.onc.1209823. PMID: 16878155.; Raafat A, Bargo S, Anver MR, Callahan R. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Oncogene. 2004 Dec 16;23(58):9401–7. doi: 10.1038/sj.onc.1208187. PMID: 15531924.; Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J. Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem. 2004 Jul 16;279(29):30771–80. doi: 10.1074/jbc.m309252200. PMID: 15123653.; MacKenzie F, Duriez P, Wong F, Noseda M, Karsan A. Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J Biol Chem. 2004 Mar 19;279(12):11657–63. doi: 10.1074/jbc.m312102200. PMID: 14701863.; Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development. Journal of Biological Chemistry. 2004 Mar;279(10):9417–23. doi: 10.1074/jbc.m312337200.; SHAWBER CJ, DAS I, FRANCISCO E, KITAJEWSKI J. Notch Signaling in Primary Endothelial Cells. Annals of the New York Academy of Sciences. 2003 May;995(1):162–70. doi: 10.1111/j.1749-6632.2003.tb03219.x.; Lin S, Oyama T, Nagase T, Harigaya K, Kitagawa M. Identification of New Human Mastermind Proteins Defines a Family That Consists of Positive Regulators for Notch Signaling. Journal of Biological Chemistry. 2002 Dec;277(52):50612–20. doi: 10.1074/jbc.m209529200.; Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J. SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation. Molecular and Cellular Biology. 2001 Nov 01;21(21):7403–15. doi: 10.1128/mcb.21.21.7403-7415.2001.; Saxena MT, Schroeter EH, Mumm JS, Kopan R. Murine Notch Homologs (N1–4) Undergo Presenilin-dependent Proteolysis. Journal of Biological Chemistry. 2001 Oct;276(43):40268–73. doi: 10.1074/jbc.m107234200.; Uyttendaele H, Ho J, Rossant J, Kitajewski J. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc. Natl. Acad. Sci. U.S.A. 2001 May 08;98(10):5643–8. doi: 10.1073/pnas.091584598.; Kusano S, Raab-Traub N. An Epstein-Barr Virus Protein Interacts with Notch. J Virol. 2001 Jan;75(1):384–95. doi: 10.1128/jvi.75.1.384-395.2001.; Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 1996 Jul;122(7):2251–9. doi: 10.1242/dev.122.7.2251. PMID: 8681805.; Robbins J, Blondel BJ, Gallahan D, Callahan R. Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J Virol. 1992 Apr;66(4):2594–9. doi: 10.1128/jvi.66.4.2594-2599.1992.; Gallahan D, Callahan R. Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J Virol. 1987 Jan;61(1):66–74. doi: 10.1128/jvi.61.1.66-74.1987.