NOTCH1 Intracellular Domain Regulates Transcription

Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A. 2011 Sep 06;108(36):14908–13. PMID: 21737748; PMCID: PMC3169118.; Arnett KL, Hass M, McArthur DG, Ilagan MXG, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature Structural & Molecular Biology. 2010 Oct 24;17(11):1312–7. doi: 10.1038/nsmb.1938.; Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints. Molecular Cell. 2008 Mar;29(6):755–66. doi: 10.1016/j.molcel.2008.01.020.; Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer. 2008 Feb;8(2):83–93. doi: 10.1038/nrc2290. PMID: 18094723.; Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl. Acad. Sci. U.S.A. 2006 Nov 28;103(48):18261–6. doi: 10.1073/pnas.0606108103.; Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10;124(5):973–83. doi: 10.1016/j.cell.2005.12.037. PMID: 16530044.; Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005 Nov;9(5):617–28. doi: 10.1016/j.devcel.2005.09.010. PMID: 16256737.; Fryer CJ, White JB, Jones KA. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004 Nov 19;16(4):509–20. doi: 10.1016/j.molcel.2004.10.014. PMID: 15546612.; Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901–11. doi: 10.1101/gad.291004.; Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20;116(4):511–26. doi: 10.1016/s0092-8674(04)00133-3. PMID: 14980219.; Wallberg AE, Pedersen K, Lendahl U, Roeder RG. p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro. Molecular and Cellular Biology. 2002 Nov 01;22(22):7812–9. doi: 10.1128/mcb.22.22.7812-7819.2002.; Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 2002 Jun 01;16(11):1397–411. PMID: 12050117; PMCID: PMC186317.; Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J. SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation. Molecular and Cellular Biology. 2001 Nov 01;21(21):7403–15. doi: 10.1128/mcb.21.21.7403-7415.2001.; Öberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U. The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog. Journal of Biological Chemistry. 2001 Sep;276(38):35847–53. doi: 10.1074/jbc.m103992200.; Leimeister C, Schumacher N, Steidl C, Gessler M. Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos. Mechanisms of Development. 2000 Nov;98(1-2):175–8. doi: 10.1016/s0925-4773(00)00459-7.; Maier MM, Gessler M. Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target Genes. Biochemical and Biophysical Research Communications. 2000 Aug;275(2):652–60. doi: 10.1006/bbrc.2000.3354.; Zhou S, Fujimuro M, Hsieh JJ-, Chen L, Miyamoto A, Weinmaster G, Hayward SD. SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function. Molecular and Cellular Biology. 2000 Apr 01;20(7):2400–10. doi: 10.1128/mcb.20.7.2400-2410.2000.; Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev. 1998 Aug 01;12(15):2269–77. PMID: 9694793; PMCID: PMC317043.; Grbavec D, Stifani S. Molecular Interaction between TLE1 and the Carboxyl-Terminal Domain of HES-1 Containing the WRPW Motif. Biochemical and Biophysical Research Communications. 1996 Jun;223(3):701–5. doi: 10.1006/bbrc.1996.0959.; Fisher AL, Ohsako S, Caudy M. The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain. Molecular and Cellular Biology. 1996 Jun 01;16(6):2670–7. doi: 10.1128/mcb.16.6.2670.; Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995 Sep 28;377(6547):355–8. doi: 10.1038/377355a0. PMID: 7566092.; Paroush Z, Finley RL, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell. 1994 Dec 02;79(5):805–15. doi: 10.1016/0092-8674(94)90070-1. PMID: 8001118.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.32 cullin-RING-type E3 NEDD8 transferase [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase


Proteins

Protein ID name full name