Activated NTRK2 signals through CDK5

Zhang H, Zhang X, Xue Q, Yan-Luo, Huang J, Zhang S, Shao H, Lu H, Wang W, Yu B. The BDNF/TrkB Signaling Pathway Is Involved in Heat Hyperalgesia Mediated by Cdk5 in Rats. PLoS ONE. 2014 Jan 21;9(1):e85536. doi: 10.1371/journal.pone.0085536.; Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506–15. PMID: 23064382; PMCID: PMC7511999.; Zhao L, Sheng AL, Huang SH, Yin YX, Chen B, Li XZ, Zhang Y, Chen ZY. Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface. J Cell Sci. 2009 Sep 01;122(Pt 17):3123–36. doi: 10.1242/jcs.047712. PMID: 19671665.; Cheung ZH, Chin WH, Chen Y, Ng YP, Ip NY. Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons. PLoS Biol. 2007 Mar 06;5(4):e63. doi: 10.1371/journal.pbio.0050063.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name