Caspase activation via extrinsic apoptotic signalling pathway

Goldschneider D, Mehlen P. Dependence receptors: a new paradigm in cell signaling and cancer therapy. Oncogene. 2010 Apr 01;29(13):1865–82. doi: 10.1038/onc.2010.13. PMID: 20173780.; Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004 Jan 23;116(2):205–19. doi: 10.1016/s0092-8674(04)00046-7. PMID: 14744432.; Hengartner MO. The biochemistry of apoptosis. Nature. 2000 Oct 12;407(6805):770–6. doi: 10.1038/35037710. PMID: 11048727.; Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. Journal of Biological Chemistry. 1993 May;268(15):10932–7. doi: 10.1016/s0021-9258(18)82075-0.; Trauth BC, Klas C, Peters AM, Matzku S, Möller P, Falk W, Debatin KM, Krammer PH. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science. 1989 Jul 21;245(4915):301–5. doi: 10.1126/science.2787530. PMID: 2787530.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.4.22.56 caspase-3
3.4.22.61 caspase-8
3.4.22.62 caspase-9


Proteins

Protein ID name full name