Pregnenolone biosynthesis

Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Stocco DM. StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol. 2001;63():193–213. doi: 10.1146/annurev.physiol.63.1.193. PMID: 11181954.

Metabolites

4-Methylpentanal

Formula: C6H12O (100.0888102)

CAS ID: 1119-16-0

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Isohexanol

Formula: C6H14O (102.10445940000001)

CAS ID: 1320-98-5

22S-hydroxycholesterol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 22348-64-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.18.1.-
1.1.1.21 aldose reductase alditol:NAD(P)+ 1-oxidoreductase
1.1.1.300 NADP-retinol dehydrogenase retinol:NADP+ oxidoreductase
1.1.1.372 D/L-glyceraldehyde reductase glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
1.1.1.54 allyl-alcohol dehydrogenase allyl-alcohol:NADP+ oxidoreductase
1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
1.18.1.6 adrenodoxin-NADP+ reductase adrenodoxin:NADP+ oxidoreductase


Proteins

Protein ID name full name