Platelet activation, signaling and aggregation

KAHNER BN, SHANKAR H, MURUGAPPAN S, PRASAD GL, KUNAPULI SP. Nucleotide receptor signaling in platelets. Journal of Thrombosis and Haemostasis. 2006 Nov;4(11):2317–26. doi: 10.1111/j.1538-7836.2006.02192.x.; Lembo G, Montrucchio G, Rommel C, Costa C, Barberis L, Hirsch E. Signaling through PI3K?: a common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb Haemost. 2006;95(01):29–35. doi: 10.1160/th05-07-0476.; Kunapuli SP, Dorsam RT, Kim S, Quinton TM. Platelet purinergic receptors. Curr Opin Pharmacol. 2003 Apr;3(2):175–80. doi: 10.1016/s1471-4892(03)00007-9. PMID: 12681240.; Ruggeri ZM. Platelets in atherothrombosis. Nat Med. 2002 Nov;8(11):1227–34. doi: 10.1038/nm1102-1227. PMID: 12411949.; Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, Wymann M, Montrucchio G. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J. 2001 Sep;15(11):2019–21. doi: 10.1096/fj.00-0810fje. PMID: 11511514.; Wagner C, Mascelli M, Neblock D, Weisman H, Coller B, Jordan R. Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets. 1996 Aug 01;88(3):907–14. doi: 10.1182/blood.v88.3.907.bloodjournal883907.; Phillips DR, Charo IF, Scarborough RM. GPIIb-IIIa: the responsive integrin. Cell. 1991 May 03;65(3):359–62. doi: 10.1016/0092-8674(91)90451-4. PMID: 2018971.; Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22;64(6):1057–68. doi: 10.1016/0092-8674(91)90261-v. PMID: 1672265.

Metabolites

2-Arachidonoylglycerol

Formula: C23H38O4 (378.2769948)

CAS ID: 53847-30-6

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase


Proteins

Protein ID name full name