TLR5 cascade

Kogut MH, Genovese KJ, He H, Kaiser P. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways. Innate Immun. 2008 Aug;14(4):213–22. doi: 10.1177/1753425908094416. PMID: 18669607.; Keestra AM, de Zoete MR, van Aubel RA, van Putten JP. Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin. Mol Immunol. 2008 Mar;45(5):1298–307. doi: 10.1016/j.molimm.2007.09.013. PMID: 17964652.; Kogut MH, Genovese KJ, He H. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1. Mol Immunol. 2007 Mar;44(7):1729–36. doi: 10.1016/j.molimm.2006.07.292. PMID: 17045653.; Iqbal M, Philbin VJ, Withanage GSK, Wigley P, Beal RK, Goodchild MJ, Barrow P, McConnell I, Maskell DJ, Young J, Bumstead N, Boyd Y, Smith AL. Identification and Functional Characterization of Chicken Toll-Like Receptor 5 Reveals a Fundamental Role in the Biology of Infection with Salmonella enterica Serovar Typhimurium. Infect Immun. 2005 Apr;73(4):2344–50. doi: 10.1128/iai.73.4.2344-2350.2005.; Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol. 2003 Dec;4(12):1247–53. doi: 10.1038/ni1011. PMID: 14625549.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)


Proteins

Protein ID name full name