DNA Repair
Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer. 2012 Dec;12(12):801–17. doi: 10.1038/nrc3399. PMID: 23175119.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.
Metabolites
2,6-diamino-5-formamido-4-hydroxypyrimidine
Formula: C5H7N5O2 (169.05997220000003)
CAS ID: 133310-38-0
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.7.- | |||
| 2.3.1.48 | histone acetyltransferase | acetyl-CoA:[protein]-L-lysine acetyltransferase | |
| 2.7.10.2 | non-specific protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 2.7.7.7 | DNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | |
| 3.1.11.2 | exodeoxyribonuclease III | ||
| 3.1.3.48 | protein-tyrosine-phosphatase | protein-tyrosine-phosphate phosphohydrolase | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.6.4.12 | DNA helicase | ||
| 3.6.4.6 | vesicle-fusing ATPase | ATP phosphohydrolase (vesicle-fusing) | |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase | |
| 5.2.1.8 | peptidylprolyl isomerase | Peptidylproline cis-trans-isomerase | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) | |
| 6.5.1.1 | DNA ligase (ATP) | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP) |
Proteins
| Protein ID | name | full name |
|---|