Cell Cycle Checkpoints

Groelly FJ, Fawkes M, Dagg RA, Blackford AN, Tarsounas M. Targeting DNA damage response pathways in cancer. Nat Rev Cancer. 2023 Feb;23(2):78–94. doi: 10.1038/s41568-022-00535-5. PMID: 36471053.; Tyson JJ, Novák B. Time-keeping and decision-making in the cell cycle. Interface Focus. 2022 Aug 06;12(4):20210075. PMID: 35860005; PMCID: PMC9184962.; Panagopoulos A, Altmeyer M. The Hammer and the Dance of Cell Cycle Control. Trends Biochem Sci. 2021 Apr;46(4):301–14. doi: 10.1016/j.tibs.2020.11.002. PMID: 33279370.; Poon RY. Cell Cycle Control: A System of Interlinking Oscillators. Methods Mol Biol. 2016;1342():3–19. doi: 10.1007/978-1-4939-2957-3_1. PMID: 26254915.; Golubnitschaja O. Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids. 2007;32(3):359–71. doi: 10.1007/s00726-006-0473-0. PMID: 17136506.; Shackelford RE, Kaufmann WK, Paules RS. Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect. 1999 Feb;107 Suppl 1():5–24. PMID: 10229703; PMCID: PMC1566366.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase


Proteins

Protein ID name full name